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In IL-13stimulated HAECs, it is specifically driven by 15LO1-PEBP1 complexcatalyzed generation of 15-HpETE-PE (7)

GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss

The rationale behind cyclical dosing connects directly to epitalon's mechanism of action

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Our hypothesis is further supported by the finding that for the sub-group of patients defined a priori as having residual schizophrenia, the effect size was larger, and indeed was largely responsible for the difference in scores between patients and controls

None of the three compounds have human safety data in pregnancy or breastfeeding, and they are not FDA-approved