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Prolonged elevation of blood glucose, as well as related adverse metabolic features such as dyslipidemia and chronic inflammation, lead ultimately to a range of debilitating health issues such as, cardiovascular disease, peripheral neuropathy, diabetic ketoacidosis, diabetic retinopathy, and diabetic nephropathy

Song et al., 2023

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Singlecell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)

For a 1-year lag period the HR was 0.83 (95% CI, 0.56-1.22), and for a 2-year lag period the HR was 0.90 (95% CI, 0.58-1.38)