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The structural requirements for efficient binding to the targeted transporter are crucial, particularly, when the prodrug has to compete against endogenous substrates, such as amino acids or glucose, having high concentrations in the body (75, 76)

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Neuroscientific research has further examined the peptides interaction with monoaminergic pathways, particularly those involving dopamine and serotonin signaling

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The dose escalation protocol successfully minimized these effects compared to immediate high-dose administration