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"It wouldn't surprise me that improving people's health this way actually slows down the ageing process," Prof Krumholz was quoted on Friday as telling the European Society of Cardiology Conference 2024, where the studies were presented

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IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Elevated zero maze The elevated zero maze (EZM [Tucker & McCabe, 2017]) was used to assess anxiety-like behaviour in an open and elevated environment

Abbreviations %: Proportion of subjects AIC: Akaike information criterion AUC: Area under the curve BP: Blood pressure bpm: Beats per minute CKD-EPI: Chronic Kidney Disease Epidemiology Collaboration CI: Confidence interval CV: Cardiovascular CVD: Cardiovascular disease CVOT: Cardiovascular outcomes trial DPP-4i: Dipeptidyl peptidase-4 inhibitor eGFR: Estimated glomerular filtration rate exenatide ER: Exenatide extended release GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist HbA 1c : Glycated hemoglobin HF: Heart failure HR: Hazard ratio JP: Japanese trial LDL-C: Low-density lipoprotein cholesterol MACE: Major adverse cardiovascular events MI: Myocardial infarction Mono: Monotherapy n: Number of subjects with events N: Number of subjects in full analysis set NNT: Number needed to treat to avoid one MACE during 1 year NYHA: New York Heart Association OAD: Oral antidiabetes drug Q: Quartile SBC: Schwarz Bayesian Information Criterion SBP: Systolic blood pressure SD: Standard deviation SE: Standard error SGLT-2i: Sodium-glucose co-transporter-2 inhibitor T2D: Type 2 diabetes References: Novo Nordisk