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Ozempic for CKD and heart disease The FLOW phase 3b clinical trial (NCT03819153) demonstrated that when Ozempic 1 mg injection was used in adults with type 2 diabetes and CKD, Ozempic demonstrated: 24% reduced the risk of kidney disease progression, kidney failure, and cardiovascular death at 3 years when compared to placebo

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Practical tip A combination of SGLT2i and GLP-1RA might theoretically improve cardiorenal benefits in patients with T2D and either ASCVD or multiple risk factors for ASCVD whose A1c remains suboptimal despite initial treatment with only one of these agents or if clinical status changes (e.g., new onset HF or CKD

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This recycling mechanism extends cellular protective capacity