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In the duodenum, pancreatic enzymes break down haptocorrin which allows the pH change to trigger the transfer of B12 to the intrinsic factor (IF) which is a protein made by the stomach

Animal Early human IBD/ulcerative-colitis trials of BPC-157 (PL-14736) reported it as safe with no reported toxicity but these clinical trials were not completed or fully published

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For researchers and clinicians, this means making decisions based on incomplete information