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Adipose tissue strongly enhances GIP secretion [19] and GIP levels are high in obese people with T2DM

The GLP-1 receptors can be found in the hypothalamus, hippocampus, and parts of the brains reward circuitry

References Forbes J, Krishnamurthy K

I have heard patients worry about bone loss with GLP1- what does the evidence say

Most strikingly, multiple trials have now shown that GLP-1 agonists can lead to the resolution of MASH, a severe form of fatty liver disease, without worsening of liver fibrosis, which is a common adverse outcome seen with some current medications

Switch to once weekly or monthly injections once desired outcome is achieved