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Additionally, rapid weight loss itselfregardless of the methodhas been associated with mood changes in some individuals, potentially due to hormonal shifts, nutritional factors, or psychological adjustment challenges

It also tends to stabilize over time

Dopamine supplementation would be evident, but this hydrophilic neurotransmitter does not cross the BBB and cannot enter the CNS due to brain endothelial tight junctions, active brain endothelial metabolism and lack of transporters [5]

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Every additional stressor on top of it compounds the cortisol load