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In the ACHIEVE-1 clinical trial, patients taking orforglipron experienced mild to moderate gastrointestinal adverse events

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Embodiment 3 [0052] Example 3: R 1 -His(R 2 Synthesis of )-Aib-OH [0053] [0054] R 1 =Fmoc, R 3 =Trt or Mmt or Mtt, R 2 =H [0055] At room temperature, weigh 62.66g of intermediate I crude product and add it to 250ml of dichloromethane, stir and dissolve, measure 188ml of trifluoroacetic acid and add it to the reaction flask, add 25.90g of triisopropylsilane, stir at room temperature for 4 hours, and the raw materials react