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In a sensitivity analysis restricted to placebo-controlled ALC monotherapy trials (4 studies), the pooled estimate also favored ALC (SMD 2.41, 95% CI 4.43 to 0.39
Weight loss is a hot topic these days
This is the mechanistic reason the 0.25 mg starting dose exists
Are there any age restrictions for using GLP-1 analogues
Overall, ADM prescribing increased slightly compared to December 2025 (+4.7%)
The 12mg cohort achieved the highest mean body weight reduction at -24.2% exceeding all published results for semaglutide (approximately -16% in the STEP trials) and tirzepatide (approximately -22.5% in SURMOUNT-1) at their respective maximum doses
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