Although there have been no head-to-head trials yet, tirzepatide could potentially lead to more significant weight loss with a comparable safety profile to semaglutide, according to an article in Frontiners in Endocrinology
all of which can have a direct impact on immunogenicity 28, 29
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References include the National Institutes of Health Office of Dietary Supplements B12 fact sheet, CDC NHANES B12 deficiency data 2018, and the joint USP/FDA 2023 quality survey on compounded GLP-1 products
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Weight loss, particularly rapid weight loss often seen with these drugs, inevitably involves the loss of both fat mass and lean body mass (muscle)