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Considerable heterogeneity across animal studies ( I 2 = 85.1%90.8%) arises from variability in cell sources, administration routes, dosing protocols, and outcome measures (252)

cylindrica displayed improvement in chlorophyll b by 18, 21, 23 and 34% at 0.01, 0.025, 0.05 and 0.1 ppm of iron sulfate, respectively, as compared to salinity treated plants

Moreover, studies show a widespread reduction in acetylcholinesterase activity, decreased neuronal arborization and dendritic spine density in specific brain regions of CKD mice

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In the case of guided protocols, they usually present greater homogeneity between batches, although the organoids generated only recapitulate a specific brain region, losing the wide structural and regional diversity that characterizes the human brain (Kim et al., 2021)