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In the future, large-scale clinical trials are the necessary procedure to verify the results revealed in animal experiments and to guarantee their clinical application to patients suffering stroke

Agron J 104:14671475

Baseline kidney-related features of enrolled patients were balanced among treatment groups, with a mean eGFR of 81.3 ml/min/1.73 m 2 and UACR of 15 mg/g [49]

Apart from the local adverse effects of these agents, the important limitation is the localization of their effect to the site of application alone

By month three, many patients report losing 3-7% of their starting body weight

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