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In clinical trials, semaglutide (Wegovy) averaged about 14.9% of body weight over 68 weeks in the STEP 1 trial, and tirzepatide (Zepbound) averaged about 20.9% at the highest studied dose in SURMOUNT-1
They believe the long-term costs of untreated obesity will far outweigh any immediate savings
For example, if you are on 15 mg weekly, your provider might reduce to 10 mg for 4-6 weeks, then to 7.5 mg, and finally to 5 mg before complete discontinuation
This route offers potential for future oral or transdermal formulations, but more research is needed before real-world use
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Glutathione precursors (NAC, alpha-lipoic acid): NAC 6001200mg daily
