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Importantly, these effects were sustained for up to three years, supporting the use of once weekly semaglutide for the long-term management of type 2 diabetes. The findings were presented at the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Hamburg

Biochim Biophys Acta 1812:888892 Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, OHuallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M (2012) Personal omics profiling reveals dynamic molecular and medical phenotypes

In a model of non-ischemic HF in dogs (tachycardiomyopathy induced by pacemakers), IV infusion of GLP-1 increases left ventricular (LV) contractility (LV dP/dt increased by 98%, stroke volume by 102%, and cardiac output by 57%) and decreases LV end-diastolic pressure, heart rate, and systemic vascular resistance

DOI: 10.1024/0300-9831.75.1.3 Spiering, B

Found naturally in the body, acetyl-l-carnitine supports the availability of acetyl-CoA, an important energy generating metabolite