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Paul and Brady also note that various single-nucleotide polymorphisms (SNPs) may influence the efficacy and bioavailability, but that at this time there is neither sufficient clinical research in this area nor are tests for these SNPs commercially available

So, it may take several years for the anemia to develop after absorption of the vitamin has stopped

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These signals help regulate various functions, from metabolism to healing

Extremes matter: patients under 50 kg often do well at the lower end, patients over 100 kg may sit at the upper end of standard ranges

Standard IM repletion often involves 1000 mcg daily for 1 week, then weekly for 4 weeks, followed by monthly maintenance