Despite the limited expression of GLP-1 receptors in the cardiac tissue, they tend to enhance the myocardial function through multiple mechanisms, including optimizing the coronary vascular smooth muscle cells, and endothelial function of the coronary microvasculature and the peripheral vessels as well, in addition to improving blood glucose control and providing alternative energy substrates like ketones and lactate
When the compounds are circulated to the liver, they are believed to help open up bile ducts and increase bile production and flow
Procedure was well explained and quick
Here are some of the main medicinal properties that have been investigated
Victoza brought in 245m of sales for Novo Nordisk in the first three months of this year, down by 23% from a year earlier, while Saxendas first-quarter sales halved to 188m
Finally, the potential effectiveness of new generation GLP-1 RA in terms of the dose- and exposure time-response still deserves further explorations