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Although several studies have reported dose-dependent protective effects of omega-3 fatty acids against chemotherapy-induced toxicity (such as reductions in oxidative stress markers and improvements in histological findings) this relationship is not consistently observed across all models

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The glutathione peroxidase also catalyzes the reduction of other organic hydroperoxides, such as lipid peroxides, to the corresponding alcohols

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The fat loss mechanism is indirect

The dominant clinical question is whether these benefits are downstream consequences of weight loss, glycemic improvement, and blood-pressure reduction, or whether they reflect direct pleiotropic actions on the vascular wall and myocardium