doi: 10.1002/leg3.130 60 ParadisE.ClaudeJ.StrimmerK
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The structural modifications extend plasma half-life from approximately 1020 minutes for native IGF-1 to approximately 2030 hours for IGF-1 LR3, producing a substantially different pharmacokinetic profile than the native molecule despite identical receptor pharmacology [1]
Mapping the growth hormoneStat5bIGF-I transcriptional circuit