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The miRNA has been shown to inhibit tumor proliferation and migration by directly repressing c-Met expression and altering the signaling of downstream cell cycle-related proteins (Lee et al., 2013)

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Investigators have studied the compound across cell-type-specific exposures, biomaterial-integrated delivery formats, and combination protocols with adjacent research compounds

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Cytotoxicity measurements were made with and without pretreatment with the CYP3A4 inhibitor ketoconazole (KCZ, 10 M) for 2 h, followed by exposure to ASMs alone or in combination (LCM, LEV, LCM + LEV, LCM + OXC)

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