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The protocol was approved by independent ethics committees or institutional review boards at each study site (a redacted protocol is provided separately)
The Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study found that youth (aged 10 to 17 years) with T2DM experienced a 20% to 35% annual decline in -cell function, which is significantly higher than the ~7% decline seen in older individuals [43-45]
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Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance (in Eng)
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