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Melanotan II selectively activated hypothalamic oxytocin neurons and potentiated central oxytocin release in the nucleus accumbens, a brain region critical for social learning and reward

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Machida, K

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What clinical data does not support: The clinical literature describes melanin gains, not a uniform deep tan

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This is a retatrutide-specific signal tied to glucagon-receptor activity

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Mechanistically, glutamine limitation decreases GSH levels and sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) glutathionylation, resulting in reduced SERCA activity 58

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