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Nrf2 is a major regulator of the cellular oxidative stress response and maintenance of redox homeostasis (Ma, 2013), and is regulated by signaling pathways such as NF-B, Notch, PI3K-AKT, and Brca-1 (Li et al., 2023a), with the PI3K/AKT signaling pathway being a sensory hair cell important regulator for survival against oxidative stress (Kucharava et al., 2019)

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Frequently Asked Questions This varies by individual, and a course of sessions is typically recommended for visible skin brightening rather than a one-off treatment

Proteins were precipitated by adding four volumes of ice-cold acetone and subsequent centrifugation (21.000 g , 20 min, 4 C)