According to Jenna Queller, MD, a board-certified dermatologist and founder of DermWorks in Boca Raton, Florida, Melanotan II is a synthetic peptide designed to mimic alpha-melanocyte-stimulating hormone (also known as -MSH), which she describes as a naturally occurring hormone that stimulates melanocytes, the pigment-producing cells in the skin. By activating these receptors, the peptide can increase melanin production and thus make skin look more tan
Table 1 Comparison of clinical parameters at baseline (Timepoint 1) with treatment phase (Timepoint 2) and off treatment phase (Timepoint 3)
For this reason, comprehensive metabolic care often includes strategies that support autonomic balance and cellular energy production alongside nutrition and movement
The access factor Perhaps the strongest argument for GLP-1 supplements is access
Purity and sterility vary widely among suppliers
Foundayo (Orforglipron) A newer option, Foundayo, approved in 2026, brings flexibility by allowing intake at any time without dietary or hydration restrictions