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The discordance between two reviewers was resolved through discussion with another reviewer (ZW) until all the researchers reached a consensus

Potential benefits of combining intermittent fasting and GLP-1 medications Pairing intermittent fasting with GLP-1 medications may offer several synergistic benefits: Enhanced weight loss: Both approaches reduce appetite and calorie intake, potentially leading to faster and more sustainable weight loss

Conditions such as Crohns, coeliac disease or previous gut surgery, and the autoimmune cause behind pernicious anaemia, all affect how well you retain B12

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Survodutide is a concrete bet on that principle, and the reason it is studied so intensively is that the bet is testable: if the glucagon axis truly adds something, it should show up as extra weight loss, extra liver-fat reduction, and a distinct safety signature relative to GLP-1 alone