New Drugs 2018, 36, 869 876 DOI: 10.1007/s10637-018-0570-4 mAbs 2019, 11, 11491161 DOI: 10.1080/19420862.2019.1618674 N-Acetyl-g-calicheamicin 1,2-dimethylhydrazine ADC (ozogamycin) Clin Cancer Res
Enzyme-cleavable linkers utilize tumor-specific protease activity, such as Cathepsin B, Cathepsin L, or matrix metalloproteinases (MMPs), to release the payload
Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy
Regular GLP-1 monitoring labs, usually every 3-6 months, help track how your body is responding to the medication
The main storage enemies are heat, light, moisture, oxygen, repeated freeze-thaw cycles, and poor sterile technique
Current evidence has not confirmed a direct causal relationship in most reported cases