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Protein binding is saturable: it decreases with increasing valproate concentration, low albumin concentrations, the patient's age, additional use of other drugs such as aspirin, as well as liver and kidney impairment
If your doctor refusal seems based on this philosophy rather than your specific medical situation, you have options
Here are representative results from separate studies involving people with type 2 diabetes who were taking metformin: Both results are extremely impressive
For someone who weighs 200 pounds, thats roughly 50 pounds versus up to 40 pounds with medication
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The combination lacks clinical trial data establishing safety and efficacy
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