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the direction of this modulation was age- and region-dependent

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However, there is a clear distinction between "toxic" and "excessive." When you take a dose that far exceeds what your body can process at one time, you aren't necessarily poisoning yourself, but you are likely overwhelming your digestive system

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Jurez E, Carranza C, Snchez G, Gonzlez M, Chvez J, Sarabia C, Torres M, Sada E