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The Women's Health Initiative, a large randomized controlled trial, reported increased risks of breast cancer, cardiovascular disease, stroke, and thromboembolic events in women taking combined estrogen and progestin therapy [11]

194 disease indications have been investigated

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WJG 25(22):27062719

28, 2025, semaglutide (Ozempic) received FDA approval to reduce the risk of kidney disease worsening, kidney failure (end-stage kidney disease) and death due to cardiovascular disease in adults with type 2 diabetes (T2DM) and chronic kidney disease (CKD)