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The downstream signaling consequences of this binding are treated separately in the companion semaglutide mechanism-of-action article

Nausea, diarrhea, vomiting, and constipation appear across all studies

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Contact a healthcare provider if you have: Severe or persistent abdominal pain Pain that radiates to your back Vomiting that doesnt stop Signs of dehydration These could indicate more serious conditions (like pancreatitis, though rare)

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Restless legs syndrome is common among female patients with fibromyalgia