Longer-duration orforglipron studies may close the gap, since GLP-1 weight loss typically continues beyond 40 weeks
The available data concerns low numbers of exposed pregnancies and lack a clear description of maternal and treatment characteristics with potential effect on neonatal outcome such as maternal BMI, drug dose and trimester of exposure
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This is because it doesn't promote production of ghrelin, the enzyme that stimulates hunger
Methods Study design and data source This retrospective cohort study used de-identified electronic medical records from the TriNetX global federated research network, which aggregates data from more than 140 healthcare institutions across 19 countries