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Gastrointestinal Issues GI side effects are the most common, especially early on: Nausea Vomiting Diarrhea Constipation These may lessen over time but can persist in some patients, leading to dehydration and nutritional deficiencies

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Cell culture Baby hamster kidney (BHK) cells stably over-expressing human, cynomolgus, rat, mouse and pig GLP-1 receptor, human glucagon receptor, human GIP receptor, human GLP-2 receptor or co-expressing hGLP-1R and cAMP response element (CRE) coupled to firefly luciferase (CRE luciferase) were generated at Novo Nordisk A/S

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In various clinical trials, doses ranging from 250 mg to 1,000 mg per day have been used without significant adverse events

This step helps identify whether further evaluation is appropriate before any consideration of use