Human data remain limited, necessitating caution
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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
In vascular experiments, nitric oxide related signaling also appears to play a central role, linking BPC-157 activity to endothelial nitric oxide synthase regulation and nitric oxide dependent cellular signaling [7]
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