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N Engl J Med 367: 13321340

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Bad dosing or not monitored therapy can induce hormonal imbalance and rare gynecomastia due to altered estrogen-to-testosterone ratios

Here are some of the benefits we are seeing: Improved blood sugar control Increased insulin sensitivity Lowered risk of nerve damage and kidney disease (this is most pertinent for diabetic patients) Lowered cholesterol levels Lowered blood pressure levels Decreased risk of stroke Decreased risk of cardiac events (like a heart attack or heart disease) Its important to point out that most of these benefits are a result of losing weight (we see these benefits after bariatric surgery as well) but some studies are showing positive benefits on their own (regardless of the amount of weight loss)

Its a little sad to have so many people out there not benefiting, said William Rosenblatt, a family doctor in Columbus who treats Hines