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Moreover, MC3R might influence feeding behavior, possibly impacting appetite and food intake, and is thought to be involved in various metabolic processes, including the potential regulation of glucose and lipid metabolism
Critically, 91% of participants maintained their weight loss through week 48 without significant regain, which addresses one of the most common concerns about obesity pharmacotherapy: whether results hold over time
Accordingly, the degree of DPP-4 inhibition attained in vivo is sufficient to increase circulating levels of intact (active) incretins by 2- to 4-fold and result in improved glycaemic control (118)
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