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In advanced cases, toxicity can lead to gastrointestinal bleeding, characterized by dark, tarry stools, or acute renal impairment

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Current areas of scientific investigation include extracellular matrix signaling analysis, peptide-metal coordination studies, redox-sensitive signaling pathway research, transcription-associated metal regulation, copper-mediated cellular signaling investigations, and matrix-associated biochemical pathway analysis

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Committee members weigh the record and may disagree about how the statutory factors should be balanced