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Sin embargo, a diferencia de los genricos qumicos que son idnticos al original, los biosimilares requieren estudios clnicos propios para demostrar que funcionan igual, lo que retrasa su llegada al mercado incluso despus del vencimiento de patentes

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The extracellular parts of TM1 and TM2 moved inward to the center, while TM7 moved outwards accompanied by conformational changes of ECL1

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