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doi: 10.1161/circgenetics.109.852814 43 WuQLiangXWangKLinJWangXWangPet al

GLP-1 alone also produced a substantial reduction (MD: 5.22 kg, 95% CI: 7.88 to 2.55, p = 0.0001)

measurable wrinkle depth and elasticity changes surface by week 8-12

Start low, even coming from a high dose Most switch protocols start tirzepatide at 2.55 mg/week regardless of the semaglutide dose someone was previously on, then re-titrate from there to limit GI side effects

Healthy fat sources Extra virgin olive oil serves as the primary cooking fat for tirzepatide users