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Beyond the rapid clearance by the reticuloendothelial system (RES) which reduces bioavailability, the dense extracellular matrix and high interstitial fluid pressure within solid tumors severely restrict the deep penetration of nanorobots, often limiting therapeutic effects to the tumor periphery

Fifth, consider starting with one agent at a low dose, then thoughtfully adding the second medication only after the first is well-tolerated

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A medication can be medically necessary and still excluded

These data, which they're working to gather now, would help contextualize whether there are any benefits of using the drugs to lose weight prior to conception, even if you then have to come off the drugs during pregnancy

doi: 10.1016/j.xpro.2024.103277 Liu X