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Interestingly, the opioid antagonist naloxone can block some of DSIPs effects, confirming this opioid system involvement

JAMA, 325(14), 1414-1425

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2-5 Similar to obesity, heart failure with preserved ejection fraction (HFpEF) is a heterogeneous multiorgan syndrome with substantial etiologic and pathophysiologic variation

[PMID: 28228068] PubMed record related to this compound for laboratory literature review