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A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)

doi: 10.1080/17425247.2023.2167978 83 PetrovMMakarovaNMonemianAPhamJLekkaMSokolovI

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Even 1 kg of extra lean mass can lower mortality risk by ~1% in middle-aged and older adults