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Targeted genetic screen in amyotrophic lateral sclerosis reveals novel genetic variants with synergistic effect on clinical phenotype
Their peroxidation products include Lipid Hydroperoxides (LOOHs) and reactive aldehydes (e.g., malondialdehyde and 4-hydroxynonenal, 4-HNE)
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Additionally, the native lysine at position 34 is substituted with arginine to prevent improper fatty acid binding at that site
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