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While these medications are FDA-approved for obesity (BMI 30 kg/m or 27 kg/m with weight-related complications) and/or type 2 diabetes, they are not specifically approved for MASLD/MASH treatment
If you are extremely sensitive and find that taking the supplement on a completely empty stomach causes mild nausea, clinical evidence suggests pairing it with a very small, light snack (such as a few bites of fruit or a cracker) can mitigate digestive discomfort while still preserving the stability of the acetylated molecule
In the liver, weight loss and improved insulin sensitivity reduce hepatocellular fat accumulation and inflammatory signaling, key drivers of MASH pathogenesis
Yang et al
One consideration involves gastrointestinal effects
