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While some studies observed sleep-promoting effects, others found minimal or inconsistent changes in sleep architecture following DSIP administration

Harvey, Denise R

In fact, many report that it feels like a switch has been flipped

For some, the absence of food noise was more significant than the weight loss. That food talk (also known as food noise) is a term used to describe the obsessive thoughts, cravings, and internal negotiations that can dominate a persons mental bandwidth

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This discrepancy might be attributable to differences in species-specific metabolism, translation of preclinical therapeutic dosages equivalent clinical doses, and the inability of observational human studies to control for all confounders