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Tirzepatide consistently outperformed semaglutide for weight loss, with the highest tirzepatide dose achieving approximately 22% body weight reduction compared to semaglutide 2.4 mg at roughly 15%

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Investigations into biased agonism, where medications are designed to selectively activate beneficial GLP-1 receptor pathways while minimizing those that cause side effects, could eventually produce GLP-1 medications with significantly reduced dry mouth profiles

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