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Patients say they were not adequately warned about the risks, which include severe gastrointestinal problems and organ damage that may require ongoing care

Concerns about whether muscle mass loss in agents associated with significant weight loss are accompanied by loss of muscle function are not yet entirely resolved

Experts say the findings underscore the need for long-term strategies to maintain weight loss and protect health after stopping medication

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The most frequently reported adverse reactions (1% or more and twice rate of placebo) were decreased appetite (2/233

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