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The individuals who started taking GLP-1RAs had 31% fewer SUD-related ER visits and 26% fewer SUD-related hospital admissions than those taking a SGLT-2

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Comprehensive toxicology studies found no lethal dose even at extremely high levels (20 mg/kg intramuscularly in rats, equivalent to approximately 1,400 mg for a 155 pound human)

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Several compounds are also in late-stage trials: Survodutide (Boehringer Ingelheim) is a dual GLP-1/glucagon agonist in Phase 3 trials

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