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This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer

and it provides antioxidant protection that reduces oxidative stress-induced hyperpigmentation

Nature 577 , 531536 (2020)

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Glutathionylation, a key mechanism of post-translational modification of proteins, involves the formation of a disulfide bridge between GSH and an available protein cysteine thiol