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Although multiple pathways are involved in mediating tissue damage, including the polyol pathway, advanced glycation end product formation, protein kinase C activation, and the hexosamine pathway, a common feature is increased oxidative stress marked by elevated levels of reactive oxygen species (ROS) (1)

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A total of 107 women aged 4065 years were tested among four different treatment groups that received the following treatments daily: treatment 1 contained 10 g of hydrolyzed fish collagen (HFC) ( n =27), treatment 2 contained 5 g of HFC plus 1.5 g of MSM ( n = 26), treatment 3 contained 10 g of HFC plus 1.5 g of MSM ( n = 27), and treatment 4 was the placebo control ( n = 27)

CXCL10 then activates CXCR3B and triggers the apoptosis of melanocytes (42)

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The APCP treatment was a commercial-grade product available in Korea, and this study was conducted to provide evidence of proof of concept