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Its interaction with the digestive system is part of why semaglutide is effective for weight loss

Physiol Behav 89: 486489, 2006

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Klausen et al., 2022), we hypothesized that, relative to vehicle, chronic semaglutide administration would reduce sign-tracking behavior, attenuate the conditioned reinforcing properties of the food cue, and diminish progressive ratio responding and free consumption of the food reward